bill bissett has published over 35 books of poetry. He is known for his use of a unique orthography and incorporating visual elements in his printed poetry, and his performance of "concrete sound" poetry, incorporating sound effects, chanting, barefoot dancing and playing a maraca during his poetry readings. He has been described as rejecting "the conventional or 'straight' world [...] not only in lifestyle but in ruthless alterations to conventional syntax and spelling." He is often associated with the Shamanistic in literature.

bissett has also had large exhibits of his paintings and made audio recordings on vinyl, cassette tape and CD. He was the lyricist and vocalist in the Ontario band, Luddites, and before that he collaborated with experimental rock group The Mandan Massacre. His work typically ranges from the mystical to the mundane, incorporating humour, a sense of wonder and sentimentality, and political commentary.